CB-7921220

CB-7921220 is an adenylate cyclase inhibitor.

Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase

Research Areas >> Cardiovascular Disease

Research Areas >> Neurological Disease

CB-7921220 shows a degree of isoform selectivity for adenylate cyclase (AC) 1, but cannot distinguish between AC1 and AC6. CB-7921220 has a more consistent predicted binding position in the two virtual docking screens, and has a binding conformation similar to ATP and P-site inhibitors, which may explain its lack of selectivity between AC1 and AC6[1].

[1]. Brand CS, et al. Isoform selectivity of adenylyl cyclase inhibitors: characterization of known and novel compounds. J Pharmacol Exp Ther. 2013 Nov;347(2):265-75.

Forskolin | SQ22536 | α-MSH trifluoroacetate salt | ST 034307 | Small Cardioactive Peptide B (SCPB)