Clopidogrel thiolactone

Names

[ Name ]:
Clopidogrel thiolactone

[Synonym ]:
(S)-methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno-[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate
(2S)-Methyl 2-(2-chlorophenyl)-2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)acetate
(2'S)-2-oxo-clopidogrel
[8S]-2-oxo-clopidogrel
clopidogrel thiolactone
Methyl (2S)-(2-chlorophenyl)(2-oxo-2,6,7,7a-tetrahydrothieno[3,2-c]pyridin-5(4H)-yl)acetate
(2S)-methyl 2-(2-oxo-7,7a-dihydrothieno[3,2-c]pyridin-5(2H,4H,6H)-yl)-2-(2-chlorophenyl)acetate
Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-2,6,7,7a-tetrahydro-2-oxo-, methyl ester, (αS)-
2-Oxoclopidogrel
methyl (2'S)-2-(2-chlorophenyl)-2-(2,4,5,6,7,7a-hexahydrothieno[3,2-c]-5-pyridin-2-one)acetate

Biological Activity

[Description]:

Clopidogrel thiolactone is a P2Y12 receptor inhibitor, is a potent antiplatelet agent.Target: P2Y12Clopidogrel thiolactone is the metabolic intermediate resulting from the first oxidative activation of clopidogrel.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> P2Y Receptor

Research Areas >> Cardiovascular Disease

[References]

[1]. Shan J, et al. Overcoming Clopidogrel Resistance: Discovery of Vicagrel as a Highly Potent and Orally Bioavailable Antiplatelet Agent

[Related Small Molecules]

Suramin sodium | MRS 2578 | Diquafosol Tetrasodium | Prasugrel | BPTU | AZD 1283 | TAK-024

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
488.1±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₆H₁₆ClNO₃S

[ Molecular Weight ]:
337.821

[ Flash Point ]:
249.0±28.7 °C

[ Exact Mass ]:
337.053955

[ PSA ]:
71.91000

[ LogP ]:
2.96

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.640

[ Storage condition ]:
2-8℃

Safety Information

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%