Boeravinone B

Names

[ Name ]:
Boeravinone B

[Synonym ]:
6,9,11-Trihydroxy-10-methyl-[1]benzopyrano[3,4-b][1]benzopyran-12(6H)-one
[1]Benzopyrano[3,4-b][1]benzopyran-12(6H)-one, 6,9,11-trihydroxy-10-methyl-
6,9,11-Trihydroxy-10-methylchromeno[3,4-b]chromen-12(6H)-one

Biological Activity

[Description]:

Boeravinone B, a dual inhibitor of NorA bacterial efflux pump of Staphylococcus aureus and human P-Glycoprotein, reduces the biofilm formation and intracellular invasion of bacteria. Boeravinone B act as anti-aging and anti-apoptosis phyto-molecules during oxidative stress[1][2].

[Related Catalog]:

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Membrane Transporter/Ion Channel >> P-glycoprotein

[In Vitro]

Boeravinone B is also active against a methicillin-resistant S. aureus (MRSA) strain, which showed a fourfold reduction in the ciprofloxacin MIC[1].

[References]

[1]. Samsher Singh, Boeravinone B, A Novel Dual Inhibitor of NorA Bacterial Efflux Pump of Staphylococcus aureus and Human P-Glycoprotein, Reduces the Biofilm Formation and Intracellular Invasion of Bacteria. Front Microbiol. 2017 Oct 4;8:1868.

[2]. Shivtej P Biradar, et al. Chebulinic acid and Boeravinone B act as anti-aging and anti-apoptosis phyto-molecules during oxidative stress. Mitochondrion. 2019 May;46:236-246.

Chemical & Physical Properties

[ Density]:
1.7±0.1 g/cm3

[ Boiling Point ]:
640.1±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₂O₆

[ Molecular Weight ]:
312.274

[ Flash Point ]:
244.3±25.0 °C

[ Exact Mass ]:
312.063385

[ PSA ]:
100.13000

[ LogP ]:
3.40

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.772

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
N

[ RIDADR ]:
NONH for all modes of transport