II-B08

Names

[ Name ]:
II-B08

[Synonym ]:
3-{1-[3-(4-Biphenylylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
3-{1-[3-(biphenyl-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl}-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid
1H-Indole-5-carboxylic acid, 3-[1-[3-([1,1'-biphenyl]-4-ylamino)-3-oxopropyl]-1H-1,2,3-triazol-4-yl]-6-hydroxy-1-methyl-2-phenyl-

Biological Activity

[Description]:

II-B08 is a reversible and noncompetitive SHP2 inhibitor (IC50: 5.5 μM, 15.7, 14.3 μM for SHP2, SHP1, PTP1B). II-B08 can be used for cancer research[1].

[Related Catalog]:

Research Areas >> Cancer

[References]

[1]. Zeng LF, et al. Therapeutic potential of targeting the oncogenic SHP2 phosphatase. J Med Chem. 2014 Aug 14;57(15):6594-609.

[2]. Zhang X, et al. Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2). J Med Chem. 2010 Mar 25;53(6):2482-93.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C₃₃H₂₇N₅O₄

[ Molecular Weight ]:
557.599

[ Exact Mass ]:
557.206299

[ LogP ]:
6.22

[ Index of Refraction ]:
1.694

Related Compounds

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