Levitide

Names

[ Name ]:
Levitide

[Synonym ]:
PYR-GLY-MET-ILE-GLY-THR-LEU-THR-SER-LYS-ARG-ILE-LYS-GLN-NH2
pGlu-Gly-Met-Ile-Gly-Thr-Leu-Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2
PYR-GMIGTLTSKRIKQ-NH2
GLP-GLY-MET-ILE-GLY-THR-LEU-THR-SER-LYS-ARG-ILE-LYS-GLN-NH2

Biological Activity

[Description]:

Levitide is a neurohormone-like peptide, can be isolated from skin secretions of the South African frog Xenopus laevis. Levitide comes from preprolevitide, is 88 residues long and contains contains the levitide peptide at the C terminus (Glu-Gly-Met-Ile-Gly-Thr-Leu-Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2) and the putative signal sequence at the N terminus[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[In Vitro]

The preprolevitide, also known as levitide precursor, exhibits a striking nucleotide and amino acid sequence homology with the precursor of xenopsin. Xenopsin is a octapeptide and also encodes a 25-residue amphipathic peptide that is released by processing at a single arginine residue[1].

[References]

[1]. Poulter L, et al. Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences. J Biol Chem. 1988 Mar 5;263(7):3279-83.

Chemical & Physical Properties

[ Density]:
1.44 g/cm3

[ Molecular Formula ]:
C₆₆H₁₁₉N₂₁O₁₉S

[ Molecular Weight ]:
1542.85000

[ Exact Mass ]:
1541.87000

[ PSA ]:
693.51000

[ LogP ]:
1.15020

[ Index of Refraction ]:
1.64

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

Levitide, a neurohormone-like peptide from the skin of Xenopus laevis. Peptide and peptide precursor cDNA sequences.

J. Biol. Chem. 263 , 3279, (1988)

A novel peptide, levitide, less than Glu-Gly-Met-Ile-Gly-Thr-Leu-Thr-Ser-Lys-Arg-Ile-Lys-Gln-NH2 has been isolated from skin secretions of the South African frog Xenopus laevis and sequenced by fast a...

The genes for the frog skin peptides GLa, xenopsin, levitide and caerulein contain a homologous export exon encoding a signal sequence and part of an amphiphilic peptide.

Eur. J. Biochem. 179(2) , 281-5, (1989)

From genomic libraries of Xenopus laevis, parts of the genes coding for the precursors of the skin peptides GLa (peptide with amino-terminal glycine and carboxy-terminal leucinamide), xenopsin and lev...

Related Compounds

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