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nor-NOHA acetate

Names

[ CAS No. ]:
1140844-63-8

[ Name ]:
nor-NOHA acetate

Biological Activity

[Description]:

nor-NOHA acetate is a specific and reversible arginase inhibitor, induces apoptosis in ARG2-expressing cells under hypoxia but not normoxia. Anti-leukemic activity, effective in endothelial dysfunction, immunosuppression and metabolism[1].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Research Areas >> Metabolic Disease
Signaling Pathways >> Immunology/Inflammation >> Arginase

[Target]

Arginase[1]


[References]

[1]. Ng KP, et al. The arginase inhibitor Nω-hydroxy-nor-arginine (nor-NOHA) induces apoptosis in leukemic cells specifically under hypoxic conditions but CRISPR/Cas9 excludes arginase 2 (ARG2) as the functional target. PLoS One. 2018 Oct 11;13(10):e0205254.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H20N4O7

[ Molecular Weight ]:
296.28

[ Storage condition ]:
2-8℃

Related Compounds