(Z)-FeCP-oxindole

Names

[ Name ]:
(Z)-FeCP-oxindole

[Synonym ]:
Iron(2+) 2,4-cyclopentadienide 2-[(Z)-(2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-cyclopentadienide (1:1:1)

Biological Activity

[Description]:

(Z)-FeCP-oxindole is a selective human vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with an IC50 value of 200 nM. (Z)-FeCP-oxindole can significantly inhibit VEGFR1 and PDGFRa or b at 10 μM. (Z)-FeCP-oxindole has some anticancer activity, acting on B16 murine melanoma lines with IC50 less than 1 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR

[References]

[1]. John Spencer, et al. Synthesis and evaluation of metallocene containing methylidene-1,3-dihydro-2H-indol-2-ones as kinase inhibitors. Metallomics. 2011 Jun;3(6):600-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₁₅FeNO

[ Molecular Weight ]:
329.173

[ Exact Mass ]:
329.050293

Related Compounds

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