Z-DEVD-AFC

Names

[ Name ]:
Z-DEVD-AFC

[Synonym ]:
N-[(Benzyloxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-L-valyl-N-[2-oxo-4-(trifluoromethyl)-2H-chromen-7-yl]-L-α-asparagine
L-α-Asparagine, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-L-valyl-N-[2-oxo-4-(trifluoromethyl)-2H-1-benzopyran-7-yl]-
Z-DEVD-AFC

Biological Activity

[Description]:

Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> Caspase

[References]

[1]. Santiago AR, et al. High glucose induces caspase-independent cell death in retinal neural cells. Neurobiol Dis. 2007;25(3):464-472.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
1160.9±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₆H₃₈F₃N₅O₁₄

[ Molecular Weight ]:
821.707

[ Flash Point ]:
655.9±34.3 °C

[ Exact Mass ]:
821.236755

[ LogP ]:
4.15

[ Vapour Pressure ]:
0.0±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.591

Related Compounds

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