AWL-II-38.3

Names

[ Name ]:
AWL-II-38.3

Biological Activity

[Description]:

AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[Target]

Ephrin-A receptor (EphA3) kinase[1][2]

[In Vitro]

AWL-II-38.3 fits to LIMK2 and LIMK1 ATP-binding and substrate-binding pockets[2].

[References]

[1]. Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.

[2]. Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₃H₁₈F₃N₅O₃

[ Molecular Weight ]:
469.42

Related Compounds

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