Apixaban-d3

Names

[ CAS No. ]:
1131996-12-7

[ Name ]:
Apixaban-d3

[Synonym ]:
Apixaban-d3

Biological Activity

[Description]:

Apixaban-d3 (BMS-562247-01-d3)is the deuterium labeledApixaban(HY-50667)[1]. Apixaban (BMS-562247-01) is a highly selective, reversible and orally active inhibitor of Factor Xa with Ki of 0.08 nM and 0.17 nM in human and rabbit, respectively[2]. Apixaban is in development for the prevention and treatment of various thromboembolic diseases[3].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₂D₃N₅O₄

[ Molecular Weight ]:
462.52

[ Exact Mass ]:
462.20900

[ PSA ]:
111.75000

[ LogP ]:
3.71380

Related Compounds

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