AZD7254

Names

[ CAS No. ]:
1126366-28-6

[ Name ]:
AZD7254

Biological Activity

[Description]:

AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC50 of 1.0 nM against sonic Hh protein (shh)[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> Smo

Research Areas >> Cancer

[In Vivo]

AZD7254 (40 mg/kg; p.o.; twice daily for 10 days) exhibits 42% tumor growth inhibition in an HT29-MEF (murine embryonic fibroblast) co-implant xenograft model[1].

[References]

[1]. Yang B, et al. Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254). Bioorg Med Chem. 2020 Jan 15;28(2):115227.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₄H₂₂N₄O₂

[ Molecular Weight ]:
398.46

Related Compounds

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