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1126366-28-6

1126366-28-6 structure

1126366-28-6 structure

Name: AZD7254
Chemical Name: AZD7254
CAS Number: 1126366-28-6
Molecular Formula: C₂₄H₂₂N₄O₂
Molecular Weight: 398.46
Catalog: Signaling Pathways Stem Cell/Wnt Smo
Create Date: 2022-08-02 15:40:32
Modify Date: 2025-08-21 10:50:15
AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC50 of 1.0 nM against sonic Hh protein (shh)[1].

Name	AZD7254

Description	AZD7254 is an orally active Smoothened (SMO) inhibitor with an EC50 of 1.0 nM against sonic Hh protein (shh)[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> Smo Research Areas >> Cancer
In Vivo	AZD7254 (40 mg/kg; p.o.; twice daily for 10 days) exhibits 42% tumor growth inhibition in an HT29-MEF (murine embryonic fibroblast) co-implant xenograft model[1].
References	[1]. Yang B, et al. Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254). Bioorg Med Chem. 2020 Jan 15;28(2):115227.

Molecular Formula	C₂₄H₂₂N₄O₂
Molecular Weight	398.46

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