AZD5213

Names

[ CAS No. ]:
1119807-02-1

[ Name ]:
AZD5213

Biological Activity

[Description]:

AZD5213 is a selective and competitive human H3 receptor antagonist with a pKi value of 9.3 for hH3R. AZD5213 can be used for the research of sleep and cognitive regulation[1][2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Neurological Disease
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[In Vivo]

AZD5213 (1 mg/kg；静脉注射一次) 迅速减少 [11C] 4-(1S,2S)-2-(4-cyclobutylpiperazine-1-carbonyl)-cyclopropyl]-N-methyl-benzamide 与小鼠大脑所有区域的结合[1]。

[References]

[1]. Schou M, et al. Discovery and Preclinical Validation of [(11)C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor. ACS Chem Neurosci. 2016 Feb 17;7(2):177-84.  

[2]. Nikolic K, et al. Procognitive properties of drugs with single and multitargeting H3 receptor antagonist activities. CNS Neurosci Ther. 2014 Jul;20(7):613-23.  

Chemical & Physical Properties

[ Molecular Formula ]:
C19H25N3O2

[ Molecular Weight ]:
327.42

Related Compounds