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7-Deaza-ddG

Names

[ CAS No. ]:
111869-49-9

[ Name ]:
7-Deaza-ddG

[Synonym ]:
MFCD07778654
4H-Pyrrolo[2,3-d]pyrimidin-4-one, 2-amino-3,7-dihydro-7-[(2R,5S)-tetrahydro-5-(hydroxymethyl)-2-furanyl]-
2-Amino-7-[(2R,5S)-5-(hydroxymethyl)tetrahydro-2-furanyl]-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

Biological Activity

[Description]:

7-Deaza-2',3'-dideoxyguanosine (7-Deaza-ddG) is a 2′,3′-dideoxynucleoside 5′-triphosphate, which can inhibit HIV-1 reverse transcriptase with a Ki of 25 nM[1].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> HIV
Research Areas >> Infection

[Target]

HIV-1


[References]

[1]. Nicholas A Boyle, et al. Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. J Med Chem. 2005 Apr 7;48(7):2695-700.

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Melting Point ]:
228 °C (decomp)

[ Molecular Formula ]:
C11H14N4O3

[ Molecular Weight ]:
250.257

[ Exact Mass ]:
250.106583

[ LogP ]:
-1.43

[ Index of Refraction ]:
1.797

[ Storage condition ]:
2-8℃

Related Compounds