Biotin-EDA

Names

[ Name ]:
Biotin-EDA

[Synonym ]:
biotinylethylenediamine
BAEA
N-Biotinyl-ethylenediamine
biotin ethylenediamine
1H-Thieno(3,4-d)imidazole-4-pentanamide,N-(2-aminoethyl)hexahydro-3-oxo-,(3aS,4S,6aR)
N-[2-(D-biotinylamino)ethyl]amine
N-(2-aminoethyl)biotinamide
N-aminoethylaminobiotin
[3aS-(3a|A,4|A,6a|A)]-N-(2-Aminoethyl)hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide
(3aS,4S,6aR)-N-(2-Aminoethyl)hexahydro-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide
Spiro[3H-azonine-3,4'-[4H]thieno[3,4-d]imidazole]-9-carboxamide, N-ethyltetradecahydro-2,2',8-trioxo-, (3S,3a'S,6a'R)-
Biotinylamidoethylacetamide
(3S,3a'S,6a'R)-N-Ethyl-2,2',8-trioxohexahydrospiro[azonane-3,4'-thieno[3,4-d]imidazole]-9-carboxamide
N-biotinyl-1,2-diaminoethane

Biological Activity

[Description]:

Biotin-EDA is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl-Chain

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
844.9±65.0 °C at 760 mmHg

[ Melting Point ]:
172-174ºC

[ Molecular Formula ]:
C₁₂H₂₂N₄O₂S

[ Molecular Weight ]:
354.425

[ Flash Point ]:
464.8±34.3 °C

[ Exact Mass ]:
354.136169

[ PSA ]:
141.70000

[ LogP ]:
-0.77

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.612

Biotin-EDA

Names

Biological Activity

Chemical & Physical Properties

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds