icFSP1

Names

[ Name ]:
icFSP1

Biological Activity

[Description]:

icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. icFSP1 does not competitively inhibit FSP1 enzyme activity, but instead triggers subcellular relocalization of FSP1 from the membrane and FSP1 condensation before ferroptosis induction, in synergism with GPX4 inhibition[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Apoptosis >> Ferroptosis

[References]

[1]. Toshitaka Nakamura, et al. Phase separation of FSP1 promotes ferroptosis. Nature. 2023 Jul;619(7969):371-377.

Chemical & Physical Properties

No Any Chemical & Physical Properties

Related Compounds

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