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Butyzamide

Names

[ CAS No. ]:
1110767-45-7

[ Name ]:
Butyzamide

Biological Activity

[Description]:

Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT
Signaling Pathways >> JAK/STAT Signaling >> JAK
Signaling Pathways >> Epigenetics >> JAK
Signaling Pathways >> Stem Cell/Wnt >> JAK
Signaling Pathways >> JAK/STAT Signaling >> STAT
Research Areas >> Others
Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK

[Target]

JAK2

STAT3

STAT5


[In Vitro]

Butyzamide (3 μM；15 分钟) 诱导 Ba/F3-hMpl 细胞中 JAK2、STAT3、STAT5 和 MAPK 的磷酸化[1]。 Butyzamide (3 μM; 48 小时) 诱导人 CD34+ 造血祖细胞产生集落形成单位-巨核细胞和多倍体巨核细胞[1]。

[In Vivo]

Butyzamide (10 mg/kg、50 mg/kg；口服；每天一次，持续 20 天) 在移植了人胎肝来源的 CD34+ 细胞的 NOG 小鼠内增加人血小板水平[1]。< br/>

[References]

[1]. Nogami W, et al. The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica. 2008 Oct;93(10):1495-504.  

Chemical & Physical Properties

[ Molecular Formula ]:
C29H32Cl2N2O5S

[ Molecular Weight ]:
591.55

Related Compounds