Squalane

Names

[ CAS No. ]:
111-01-3

[ Name ]:
Squalane

[Synonym ]:
Squalane
Robane
Cosbiol
Perhydrosqualene
2,6,10,15,19,23-hexamethylteracosane
Spinacane
2,6,10,15,19,23-Hexamethyltetracosane
Dodecahydrosqualene
2,6,10,15,19,23-Hexamethyltetracosane,Cosbiol,Perhydrosqualene
Vitabiosol
MFCD00008953
Hexamethyltetracosane
EINECS 203-825-6
Tetracosane, 2,6,10,15,19,23-hexamethyl-
poly(ethylenepropylene)

Biological Activity

[Description]:

Squalane, found in certain fish oils (especially shark liver oil), and some vegetable oils, is a saturated derivative of Squalene. Squalane shows anticancer, antioxidant, skin hydrating, and emollient activities[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Squalane exhibits a huge potential in nutraceutical and pharmaceutical industries. Squalane shows anticancer, antioxidant, drug carrier, detoxifier, skin hydrating, and emollient activities have been reported both in animal models and in vitro environments[1].

[References]

[1]. Kim SK, et al. Biological importance and applications of squalene and squalane. Adv Food Nutr Res. 2012;65:223-33.

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
470.3±0.0 °C at 760 mmHg

[ Melting Point ]:
−38 °C(lit.)

[ Molecular Formula ]:
C₃₀H₆₂

[ Molecular Weight ]:
422.813

[ Flash Point ]:
217.8±0.0 °C

[ Exact Mass ]:
422.485138

[ LogP ]:
15.59

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.448

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XB6070000

CHEMICAL NAME :: Tetracosane, 2,6,10,15,19,23-hexamethyl-

CAS REGISTRY NUMBER :: 111-01-3

BEILSTEIN REFERENCE NO. :: 0776019

LAST UPDATED :: 199709

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C30-H62

MOLECULAR WEIGHT :: 422.92

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: CTOIDG Cosmetics and Toiletries. (Allured Pub. Corp., POB 318, Wheaton, IL 60189) V.91- 1976- Volume(issue)/page/year: 94(8),41,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84063 No. of Facilities: 109 (estimated) No. of Industries: 3 No. of Occupations: 10 No. of Employees: 20918 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84063 No. of Facilities: 1980 (estimated) No. of Industries: 11 No. of Occupations: 32 No. of Employees: 149812 (estimated) No. of Female Employees: 126648 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
XB6070000

[ HS Code ]:
2901100000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2901100000

[ Summary ]:
2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%

Articles

Biological importance and applications of squalene and squalane.

Adv. Food Nutr. Res. 65 , 223-33, (2012)

Squalene is a polyunsaturated hydrocarbon with a formula of C₃₀H₅₀. Squalene can be found in certain fish oils, especially shark liver oil, in high amounts and some vegetable oils in relatively smalle...

How membrane permeation is affected by donor delivery solvent.

Phys. Chem. Chem. Phys. 14(44) , 15525-38, (2012)

We investigate theoretically and experimentally how the rate and extent of membrane permeation is affected by switching the donor delivery solvent from water to squalane for different permeants and me...

Effects of squalene/squalane on dopamine levels, antioxidant enzyme activity, and fatty acid composition in the striatum of Parkinson's disease mouse model.

J. Oleo Sci. 62(1) , 21-8, (2013)

Active oxygen has been implicated in the pathogenesis of Parkinson's disease (PD); therefore, antioxidants have attracted attention as a potential way to prevent this disease. Squalene, a natural trit...

Related Compounds

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