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KY-556

Names

[ CAS No. ]:
110816-78-9

[ Name ]:
KY-556

[Synonym ]:
2-(L-lysyloxy)-1,3-bis(2-ethoxycarbonylchromon-5-yloxy)propane dihydrochloride
ethyl 5-[2-[(2S)-2,6-diaminohexanoyl]oxy-3-(2-ethoxycarbonyl-4-oxochromen-5-yl)oxypropoxy]-4-oxochromene-2-carboxylate dihydrochloride
diethyl L-lysylcromoglycate dihydrochloride
Cromoglicate lisetil hydrochloride (JAN)
1,3-Bis-(2-ethoxycarbonylchromon-5-yloxy)-2-(lysyloxy)propane
KY 556
L-Lysine,2-((2-(ethoxycarbonyl)-4-oxo-4H-1-benzopyran-5-yl)oxy)-1-(((2-(ethoxycarbonyl)-4-oxo-4H-1-benzopyran-5-yl)oxy)methyl)ethyl ester,dihydrochloride
KY-556

Biological Activity

[Description]:

KY-556 is a promising and orally-active pro-drug of disodium cromoglycate (DSCG) against allergic diseases.

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Inflammation/Immunology

[In Vivo]

The oral anti-allergic effect of KY-556 (N-556) is investigated. N-556 (10-100 mg/kg, p.o.) inhibits dose-dependently the 48-hr homologous passive cutaneous anaphylaxis (PCA) in rats, and the duration of action is longer than that of intravenous Disodium cromoglycate (DSCG). N-556 (20 and 100 mg/kg once a day for 20 consecutive days, p.o.) tends to inhibit the histamine release from actively sensitized rat lung fragments. N-556 (100 mg/kg, p.o.) shows the prolongation of survival time in the rat systemic anaphylaxis. N-556 (100 mg/kg, p.o.) significantly inhibits the increased airway resistance in experimental asthma in rats[1].

[References]

[1]. Nakamura S, et al. Effects of N-556 on experimental allergy models in rats. Arerugi. 1990 Dec;39(12):1621-8.


[Related Small Molecules]

Captisol | Cyclosporin A | H2DCFDA | 0MPTP hydrochloride | GW4869 | Etomoxir | TD139 | Mitoquinone mesylate | GSK2795039 | JC-1 | BAPTA-AM | AP 20187 | Setanaxib (GKT137831) | D-Luciferin | Crotaline

Chemical & Physical Properties

[ Boiling Point ]:
789.7ºC at 760mmHg

[ Molecular Formula ]:
C33H38Cl2N2O12

[ Molecular Weight ]:
725.56700

[ Flash Point ]:
212.5ºC

[ Exact Mass ]:
724.18000

[ PSA ]:
209.82000

[ LogP ]:
6.08330

[ Vapour Pressure ]:
6.46E-25mmHg at 25°C

[ Storage condition ]:
2-8℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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