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Gelsemiol

Names

[ CAS No. ]:
110414-77-2

[ Name ]:
Gelsemiol

[Synonym ]:
2H-Cyclopenta[b]furan-2-one, hexahydro-3,4-bis(hydroxymethyl)-5-methyl-, (3R,3aS,4R,5S,6aS)-
(3R,3aS,4R,5S,6aS)-3,4-Bis(hydroxymethyl)-5-methylhexahydro-2H-cyclopenta[b]furan-2-one

Biological Activity

[Description]:

Gelsemiol is the main active ingredient in Verbena littoralis H. B. K.. Gelsemiol enhanced nerve growth factor (NGF) -induced axonal elongation in PC12D cells[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vitro]

Gelsemiol (30-300μM; 48 h) 在 PC12D 细胞中，不单独显示神经炎诱导活性[1]。 Gelsemiol (30-300μM; 48 h) 在 PC12D 细胞中，和 NGF (2 ng/mL) 一起显著增强了携带轴突的细胞比例的增加和轴突长度的延长[1]。

[References]

[1]. Li YS, et al. Potentiation of nerve growth factor-induced elongation of neurites by gelsemiol and 9-hydroxysemperoside aglucone in PC12D cells. J Pharm Pharmacol. 2001 Jun;53(6):915-9.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
407.0±10.0 °C at 760 mmHg

[ Molecular Formula ]:
C10H16O4

[ Molecular Weight ]:
200.232

[ Flash Point ]:
164.2±12.5 °C

[ Exact Mass ]:
200.104858

[ PSA ]:
66.76000

[ LogP ]:
-1.33

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.499

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds