Tirilazad

Names

[ CAS No. ]:
110101-66-1

[ Name ]:
Tirilazad

[Synonym ]:
Pregna-1,4,9(11)-triene-3,20-dione,21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)erazinyl)-16-methyl-,(16alpha)
tirilazad of tirilazad
Tirilazad
Tirilazad (INN)
Tirilazad [INN:BAN]
Tirilazadum
Tirilazadum [INN-Latin]

Biological Activity

[Description]:

Tirilazad is a nonglucocorticoid, 21-aminosteroid that inhibits lipid peroxidation. Tirilazad can attenuate brain or spinal cord injury caused by trauma, stroke, ischemia and reperfusion injury. Tirilazad has antiviral activities against nCoV. Tirilazad is neuroprotective for ischaemic stroke, can be used for subarachnoid hemorrhage research[1][2][3].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[References]

[1]. Bath PM, et al. Tirilazad for acute ischaemic stroke. Cochrane Database Syst Rev. 2001;(4):CD002087.

[2]. Zhang S, et al. Tirilazad for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2010 Feb 17;(2):CD006778.

[3]. Tirilazad mesylate in acute ischemic stroke: A systematic review. Tirilazad International Steering Committee. Stroke. 2000 Sep;31(9):2257-65.

Chemical & Physical Properties

[ Density]:
1.25g/cm3

[ Boiling Point ]:
812.9ºC at 760mmHg

[ Molecular Formula ]:
C38H52N6O2

[ Molecular Weight ]:
624.86

[ Flash Point ]:
445.4ºC

[ Exact Mass ]:
624.41500

[ PSA ]:
72.88000

[ LogP ]:
5.59120

[ Vapour Pressure ]:
1.71E-26mmHg at 25°C

[ Index of Refraction ]:
1.646

Related Compounds

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