trans-1,4-Dichlorobutene
Names
[ CAS No. ]:
110-57-6
[ Name ]:
trans-1,4-Dichlorobutene
[Synonym ]:
2-Butene, 1,4-dichloro-, (E)-
Toluene,2,5-dichloro
trans-1,4-Dichlorobutene
(2E)-1,4-Dichloro-2-butene
1,4-Dichloro-2-butene
Benzene,1,4-dichloro-2-methyl
trans 1,4-Dichloro-2-butene
(E)-1,4-Dichloro-2-butene
EINECS 203-779-7
TRANS-1,4-DICHLORO-2-BUTYLENE
2,5-dichloro-toluene
2,5-Dichlor-toluol
1,4-dichloro-toluene
MFCD00000988
TRANS-1,4-DICHLOROBUT-2-ENE
4-01-00-00787 (Beilstein Handbook Reference)
2-Butene, 1,4-dichloro-, (2E)-
(2E)-1,4-dichlorobut-2-ene
but-2-ene, trans-1,4-dichloro-
Toluene,5-dichloro
1,4-dichloro-2-methyl-benzene
TRANS-1,4-DICHLOR-2-BUTENE
1,4-Dichloro-trans-2-butene
2-Butene, 1,4-dichloro-, trans-
trans-1,4-Dichloro-2-butene
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
155.5±0.0 °C at 760 mmHg
[ Melting Point ]:
1-3ºC(lit.)
[ Molecular Formula ]:
C4H6Cl2
[ Molecular Weight ]:
124.996
[ Flash Point ]:
54.4±0.0 °C
[ Exact Mass ]:
123.984657
[ LogP ]:
1.97
[ Vapour Pressure ]:
3.9±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.459
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EM4903000
- CHEMICAL NAME :
- 2-Butene, 1,4-dichloro-, (E)-
- CAS REGISTRY NUMBER :
- 110-57-6
- BEILSTEIN REFERENCE NO. :
- 1719693
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C4-H6-Cl2
- MOLECULAR WEIGHT :
- 125.00
- WISWESSER LINE NOTATION :
- G2U2G -T
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 86 ppm/4H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - other changes Gastrointestinal - changes in structure or function of salivary glands
- REFERENCE :
- AIHAM* Annual Meeting of American Industrial Hygiene Association. (Akron, OH) For publisher information, see AIHAAP. Volume(issue)/page/year: -,-,1968 ** TUMORIGENIC DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg/77W-I
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,2553,1975
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg/77W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Tumorigenic - tumors at site of application
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 35,2553,1975 *** REVIEWS *** IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,149,1977 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 15,149,1977 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
Safety Information
[ Symbol ]:
GHS02, GHS05, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H226-H301-H312-H314-H330
[ Precautionary Statements ]:
P260-P280-P284-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T+,T,F,N
[ Risk Phrases ]:
R10
[ Safety Phrases ]:
53-23-26-36/37/39-45-36/37-99-61-60
[ RIDADR ]:
UN 3390 6.1/PG 1
[ WGK Germany ]:
3
[ RTECS ]:
EM4903000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
[ HS Code ]:
2903299090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2903299090
[ Summary ]:
2903299090 other unsaturated chlorinated derivatives of acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
Bioorg. Med. Chem. 16 , 5720-32, (2008)
The risk of the presence of haloacetic acids in drinking water as chlorination by-products and the shortage of experimental mutagenicity data for most of them requires a research work. This paper desc...
Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogues of neplanocin A.J. Med. Chem. 30(2) , 437-40, (1987)
Alkylation of adenine (5a) or 2-amino-6-chloropurine (5b) with excess trans-1,4-dichloro-2-butene (4), effected by K2CO3 in dimethyl sulfoxide or tetra-n-butylammonium fluoride in tetrahydrofuran, led...
Effect of isomers of swainsonine on glycosidase activity and glycoprotein processing.Biochemistry 26(9) , 2502-10, (1987)
The chemical synthesis of swainsonine [(1S,2R,8R,8 alpha R)-trihydroxyindolizidine] from trans-1,4-dichloro-2-butene was previously described [Adams, C. E., Walker, F. J., & Sharpless, K. B. (1985) J....