3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-d ihydro-1,3-thiazol-2-yl)benzamide

Names

[ CAS No. ]:
1092788-09-4

[ Name ]:
3-(4-Amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-N-(4,5-d ihydro-1,3-thiazol-2-yl)benzamide

Biological Activity

[Description]:

PP30, a TORKinib, is a potent, selective, and ATP-competitive inhibitor of mTOR with an IC50 of 80 nM.

[Related Catalog]:

Signaling Pathways >> PI3K/Akt/mTOR >> mTOR

Research Areas >> Cancer

Signaling Pathways >> PI3K/Akt/mTOR >> PI3K

[Target]

p110δ:0.99 μM (IC50)

p110γ:0.68 μM (IC50)

[References]

[1]. Morris E Feldman, et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol. 2009 Feb 10;7(2):e38.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₁₉N₇OS

[ Molecular Weight ]:
381.45500

[ Exact Mass ]:
381.13700

[ PSA ]:
139.87000

[ LogP ]:
3.08060

Related Compounds

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