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Ensituximab

Names

[ CAS No. ]:
1092658-06-4

[ Name ]:
Ensituximab

Biological Activity

[Description]:

Ensituximab (NEO-102; NPC-1C) is a chimeric monoclonal IgG1 antibody targeting a variant of MUC5AC. Ensituximab shows specificity to colorectal and pancreatic cancer[1][2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[In Vitro]

Ensituximab (NPC-1C) 是一种嵌合 IgG1 单克隆抗体，在结合其靶标后促进抗体依赖性细胞的细胞毒性，MUC5AC 是一种肿瘤特异性变体，一种由结直肠癌 (CRC) 和胰腺癌特异性表达的抗原[1]。

[References]

[1]. Richard D Kim, et al. Phase II Study of Ensituximab, a Novel Chimeric Monoclonal Antibody, in Adults with Unresectable, Metastatic Colorectal Cancer. Clin Cancer Res. 2020 Jul 15;26(14):3557-3564.  

[2]. Julian A Marin-Acevedo, et al. Cancer immunotherapy beyond immune checkpoint inhibitors. J Hematol Oncol. 2018 Jan 12;11(1):8.  

Chemical & Physical Properties

No Any Chemical & Physical Properties