H7

Names

[ Name ]:
H7

[Synonym ]:
UNII:55VT8U9HB1
Piperazine, 1-(5-isoquinolinylsulfonyl)-2-methyl-, dihydrochloride
5-[(2-Methyl-1-piperazinyl)sulfonyl]isoquinoline dihydrochloride
1-(5-Isoquinolinesulfonyl)-2-methyl-piperazine dihydrochloride
5-[(2-Methylpiperazin-1-yl)sulfonyl]isoquinoline dihydrochloride
Isoquinoline, 5-[(2-methyl-1-piperazinyl)sulfonyl]-, hydrochloride (1:2)
1-(5-Isoquinolinesulfonyl)-2-methylpiperazine Dihydrochloride
MFCD00036961
H-7 DIHYDROCHLORIDE
1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine dihydrochloride

Biological Activity

[Description]:

PKC-IN-5 (compound H-7) is a potent PKC (protein kinase C) inhibitor. At 100 μM, PKC-IN-5 completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase)[1].

[Related Catalog]:

Signaling Pathways >> Epigenetics >> PKC

Research Areas >> Cancer

Signaling Pathways >> TGF-beta/Smad >> PKC

[References]

[1]. Fischer SM, et al. Mediation of phorbol ester-induced oxidant generation in murine epidermal cells by protein kinase C. Toxicol In Vitro. 1989;3(3):195-9.

Chemical & Physical Properties

[ Boiling Point ]:
495.3ºC at 760mmHg

[ Melting Point ]:
215-225 °C

[ Molecular Formula ]:
C₁₄H₁₉Cl₂N₃O₂S

[ Molecular Weight ]:
364.291

[ Flash Point ]:
253.3ºC

[ Exact Mass ]:
363.057495

[ PSA ]:
70.68000

[ LogP ]:
4.16870

[ Vapour Pressure ]:
6E-10mmHg at 25°C

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: 20 mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2935009090

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

PKC enhances the capacity for secretion by rapidly recruiting covert voltage-gated Ca2+ channels to the membrane.

J. Neurosci. 35(6) , 2747-65, (2015)

It is unknown whether neurons can dynamically control the capacity for secretion by promptly changing the number of plasma membrane voltage-gated Ca(2+) channels. To address this, we studied peptide r...

Related Compounds

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