U0124

Names

[ Name ]:
U0124

[Synonym ]:
1,4-Diamino-1,4-bismethylthio-butadien-2,3-dicarbonitril
HMS3268M04

Biological Activity

[Description]:

U0124, an inactive U0126 analog, has no effect on c-Fos and c-Jun protein or mRNA levels. U0126 is a MEK inhibitor. U0124 does not inhibit MEK at concentrations up to 100 μM[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> MAPK/ERK Pathway >> MEK

[References]

[1]. M F Favata, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 1998 Jul 17;273(29):18623-32.

Chemical & Physical Properties

[ Density]:
1.338g/cm3

[ Boiling Point ]:
344.9ºC at 760mmHg

[ Molecular Formula ]:
C₈H₁₀N₄S₂

[ Molecular Weight ]:
226.32200

[ Flash Point ]:
162.4ºC

[ Exact Mass ]:
226.03500

[ PSA ]:
150.22000

[ LogP ]:
2.50076

[ Vapour Pressure ]:
6.37E-05mmHg at 25°C

[ Index of Refraction ]:
1.647

Related Compounds

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