108923-79-1

108923-79-1 structure

Name: U0124
Chemical Name: 2,3-bis[amino(methylsulfanyl)methylidene]butanedinitrile
CAS Number: 108923-79-1
Molecular Formula: C₈H₁₀N₄S₂
Molecular Weight: 226.32200
Catalog: Signaling Pathways MAPK/ERK Pathway MEK
Create Date: 2017-08-31 05:37:30
Modify Date: 2025-09-20 10:38:35
U0124, an inactive U0126 analog, has no effect on c-Fos and c-Jun protein or mRNA levels. U0126 is a MEK inhibitor. U0124 does not inhibit MEK at concentrations up to 100 μM[1].

Name	2,3-bis[amino(methylsulfanyl)methylidene]butanedinitrile
Synonyms	1,4-Diamino-1,4-bismethylthio-butadien-2,3-dicarbonitril HMS3268M04

Description	U0124, an inactive U0126 analog, has no effect on c-Fos and c-Jun protein or mRNA levels. U0126 is a MEK inhibitor. U0124 does not inhibit MEK at concentrations up to 100 μM[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> MEK
References	[1]. M F Favata, et al. Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem. 1998 Jul 17;273(29):18623-32.