GRL-0496

Names

[ Name ]:
GRL-0496

Biological Activity

[Description]:

GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> SARS-CoV

[Target]

IC50: 30 nM (SARS-CoV 3CLpro)[1]

[In Vitro]

GRL-0496 shows the best SARS-CoV antiviral activity, with an EC EC50 of 6.9 μM[1].

[References]

[1]. Ghosh AK, et, al. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₉ClN₂O₂

[ Molecular Weight ]:
272.69

Related Compounds

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