Boc-NH-PEG2-CH2COOH

Names

[ Name ]:
Boc-NH-PEG2-CH2COOH

[Synonym ]:
2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-azatridecan-13-oic acid
8-tert-Butyloxycarbonylamino-3,6-dioxaoctanoic Acid
AmbotzBAA1466
Boc-AEEA
2-[2-[2-(Boc-amino)ethoxy]ethoxy]acetic Acid

Biological Activity

[Description]:

Boc-NH-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2020 Feb 1;187:111952.

Chemical & Physical Properties

[ Boiling Point ]:
630.4°C

[ Melting Point ]:
240°C

[ Molecular Formula ]:
C₁₁H₂₁NO₆

[ Molecular Weight ]:
263.28800

[ Exact Mass ]:
263.13700

[ PSA ]:
97.58000

[ LogP ]:
0.83330

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%