β-Methylcrotonyl coenzyme A lithium

Names

[ Name ]:
β-Methylcrotonyl coenzyme A lithium

[Synonym ]:
S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 3-methylbut-2-enethioate,lithium
trans-3-Methyl-2-butenoyl Coenzyme A

Biological Activity

[Description]:

β-Methylcrotonyl coenzyme A lithium is an intermediate in leucine metabolism and can be used as a substrate to study the specificity and kinetics of β-methylcrotonyl coenzyme A carboxylase (MCCase)[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

β-Methylcrotonyl coenzyme A carboxylase, which is involved in amino acid metabolism, induces the activity of this enzyme in plant cells due to carbohydrate starvation and can be used as a new biochemical marker of the starvation-triggered autophagy process[1].

[References]

[1]. S Aubert, et al. Induction of beta-methylcrotonyl-coenzyme A carboxylase in higher plant cells during carbohydrate starvation: evidence for a role of MCCase in leucine catabolism. FEBS Lett. 1996 Apr 1;383(3):175-80.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₄₂LiN₇O₁₇P₃S

[ Molecular Weight ]:
856.57600

[ Exact Mass ]:
856.17300

[ PSA ]:
425.34000

[ LogP ]:
1.89270

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-26-36

[ RIDADR ]:
NONH for all modes of transport

Articles

Regulation of [beta]-Methylcrotonyl-Coenzyme A Carboxylase Activity by Biotinylation of the Apoenzyme.

Plant Physiol. 108 , 1133-1139, (1995)

Regulation of the expression of the gene(s) coding for the 78-kD, biotin-containing subunit of [beta]-methylcrotonyl-coenzyme A carboxylase (MCCase) was investigated in different organs of tomato (Lyc...

Induction of beta-methylcrotonyl-coenzyme A carboxylase in higher plant cells during carbohydrate starvation: evidence for a role of MCCase in leucine catabolism.

FEBS Lett. 383 , 175-180, (1996)

Induction of beta-methylcrotonyl-coenzyme A carboxylase (MCCase) activity was observed during carbohydrate starvation in sycamore cells. In mitochondria isolated from starved cells, we noticed a marke...

Essential arginine residues in the active sites of propionyl CoA carboxylase and beta-methylcrotonyl CoA carboxylase.

Enzyme 24 , 302-306, (1979)

At least one arginine residue is essential for substrate binding in or near the active sites of propionyl CoA carboxylase (PCC) and beta-methylcrotonyl CoA carboxylase (beta MCC) in cultured human fib...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.