Propane,2,2'-oxybis[1-chloro-
Names
[ CAS No. ]:
108-60-1
[ Name ]:
Propane,2,2'-oxybis[1-chloro-
[Synonym ]:
EINECS 203-598-3
Bis(2-chloroisopropyl) Ether
2-Chloroisopropyl ether
2,2’-oxybis(1-chloropropane)
2,2’-oxybis[1-chloropropane]
bis(2-chloro-1-methylethyl) ether
BIS(2-CHLOROISOPROPYL)ETHER
Chemical & Physical Properties
[ Density]:
1.086 g/cm3
[ Boiling Point ]:
187ºC at 760 mmHg
[ Melting Point ]:
-97 to -102ºC
[ Molecular Formula ]:
C6H12Cl2O
[ Molecular Weight ]:
171.06500
[ Flash Point ]:
11 °C
[ Exact Mass ]:
170.02700
[ PSA ]:
9.23000
[ LogP ]:
2.95280
[ Vapour Pressure ]:
0.887mmHg at 25°C
[ Index of Refraction ]:
1.436
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- KN1750000
- CHEMICAL NAME :
- Ether, bis(2-chloro-1-methylethyl)
- CAS REGISTRY NUMBER :
- 108-60-1
- BEILSTEIN REFERENCE NO. :
- 1735833
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 22
- MOLECULAR FORMULA :
- C6-H12-Cl2-O
- MOLECULAR WEIGHT :
- 171.08
- WISWESSER LINE NOTATION :
- G1Y1&OY1&1G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 240 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 700 ppm/5H
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - iritis Lungs, Thorax, or Respiration - dyspnea Liver - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 296 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 3 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 11250 mg/kg/45D-I
- TOXIC EFFECTS :
- Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Blood - changes in leukocyte (WBC) count
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2340 mg/kg/26W-I
- TOXIC EFFECTS :
- Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - other Enzymes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 364 gm/kg/2Y-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Blood - changes in spleen Nutritional and Gross Metabolic - weight loss or decreased weight gain
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4424 mg/kg/14D-I
- TOXIC EFFECTS :
- Related to Chronic Data - death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 876 gm/kg/2Y-C
- TOXIC EFFECTS :
- Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Rodent - hamster Ovary
- DOSE/DURATION :
- 11300 ug/L
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 10(Suppl 10),1,1987 *** REVIEWS *** IARC Cancer Review:Animal Limited Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,149,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 41,149,1986 IARC Cancer Review:Group 3 IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H301-H332
[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P261
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
26-45-36/37-16-7
[ RIDADR ]:
2490
[ RTECS ]:
KN1750000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1(a)
[ HS Code ]:
2909199012
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2909199012
[ Summary ]:
2909199012 1-chloro-2-((1-chloropropan-2-yl)oxy)propane。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:13.0%。MFN tarrif:5.5%。general tariff:30.0%
Articles
IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 41 , 149-60, (1986)
Bis(2-chloro-1-methylethyl)ether.
IARC Monogr. Eval. Carcinog. Risks Hum. 71 Pt 3 , 1275-9, (1999)
PCBs and DDE in tree swallow (Tachycineta bicolor) eggs and nestlings from an estuarine PCB superfund site, New Bedford Harbor, MA, U.S.A.
Environ. Sci. Technol. 43(21) , 8387-92, (2009)
While breeding tree swallows (Tachycineta bicolor) have been used as biomonitors for freshwater sites, we report the first use of this species to assess contaminant bioaccumulation from estuarine bree...