1-Chloro-2-propanol

Names

[ CAS No. ]:
127-00-4

[ Name ]:
1-Chloro-2-propanol

[Synonym ]:
.α.-Propylene chlorohydrin
2-Propanol, 1-chloro-
sec-Propylene Chlorohydrin
EINECS 204-819-6
1-Chloro-2-propanol
Chloropropanol,Propylene chlorohydrin
Propylene chlorohydrin
UNII:ZL0FUS96WW
MFCD00004530

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
126.5±0.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃H₇ClO

[ Molecular Weight ]:
94.540

[ Flash Point ]:
54.5±15.3 °C

[ Exact Mass ]:
94.018539

[ PSA ]:
20.23000

[ LogP ]:
0.27

[ Vapour Pressure ]:
5.4±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.424

[ Stability ]:
Stable. Flammable. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UA8942000

CHEMICAL NAME :: 2-Propanol, 1-chloro-

CAS REGISTRY NUMBER :: 127-00-4

BEILSTEIN REFERENCE NO. :: 0773653

LAST UPDATED :: 199712

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C3-H7-Cl-O

MOLECULAR WEIGHT :: 94.55

WISWESSER LINE NOTATION :: QY1&1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1000 ppm/4H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TEST SYSTEM :: Insect - Drosophila melanogaster

DOSE/DURATION :: 1 ppb

REFERENCE :: EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 23,51,1994

Safety Information

[ Symbol ]:

GHS02, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H301 + H331-H315-H319-H335

[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P210-P261-P304 + P340 + P312-P370 + P378-P403 + P233

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R10

[ Safety Phrases ]:
26-36/39

[ RIDADR ]:
UN 2611 6

[ WGK Germany ]:
3

[ RTECS ]:
UA8942000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2905590090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2905590090

[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

NTP Toxicology and Carcinogenesis Studies of 1-Chloro-2-propanol (Technical Grade) (CAS NO. 127-00-4) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies.

Natl. Toxicol. Program Tech. Rep. Ser. 477 , 1-264, (1998)

1-Chloro-2-propanol and its positional isomer, 2-chloro-1-propanol, are used as chemical intermediates for the manufacture of propylene oxide, a starting material for production of polyurethane polyol...

Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program.

Environ. Mol. Mutagen. 23(1) , 51-63, (1994)

Fifty chemicals were tested for mutagenic activity in post-meiotic and meiotic germ cells of male Drosophila melanogaster using the sex-linked recessive lethal (SLRL) assay. As in the previous studies...

Haloperoxidases: Enzymatic Synthesis of alpha,beta-Halohydrins from Gaseous Alkenes.

Appl. Environ. Microbiol. 45(2) , 366-74, (1983)

The enzymatic synthesis of alpha,beta-halohydrins from gaseous alkenes is described. The enzymatic reaction required an alkene, a halide ion, dilute hydrogen peroxide, and a haloperoxidase enzyme. A w...