1-Chloro-2-propanol
Names
[ CAS No. ]:
127-00-4
[ Name ]:
1-Chloro-2-propanol
[Synonym ]:
.α.-Propylene chlorohydrin
2-Propanol, 1-chloro-
sec-Propylene Chlorohydrin
EINECS 204-819-6
1-Chloro-2-propanol
Chloropropanol,Propylene chlorohydrin
Propylene chlorohydrin
UNII:ZL0FUS96WW
MFCD00004530
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
126.5±0.0 °C at 760 mmHg
[ Molecular Formula ]:
C3H7ClO
[ Molecular Weight ]:
94.540
[ Flash Point ]:
54.5±15.3 °C
[ Exact Mass ]:
94.018539
[ PSA ]:
20.23000
[ LogP ]:
0.27
[ Vapour Pressure ]:
5.4±0.4 mmHg at 25°C
[ Index of Refraction ]:
1.424
[ Stability ]:
Stable. Flammable. Incompatible with strong oxidizing agents.
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UA8942000
- CHEMICAL NAME :
- 2-Propanol, 1-chloro-
- CAS REGISTRY NUMBER :
- 127-00-4
- BEILSTEIN REFERENCE NO. :
- 0773653
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C3-H7-Cl-O
- MOLECULAR WEIGHT :
- 94.55
- WISWESSER LINE NOTATION :
- QY1&1G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1000 ppm/4H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA
- TEST SYSTEM :
- Insect - Drosophila melanogaster
- DOSE/DURATION :
- 1 ppb
- REFERENCE :
- EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987- Volume(issue)/page/year: 23,51,1994
Safety Information
[ Symbol ]:
GHS02, GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H226-H301 + H331-H315-H319-H335
[ Precautionary Statements ]:
Missing Phrase - N15.00950417-P210-P261-P304 + P340 + P312-P370 + P378-P403 + P233
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R10
[ Safety Phrases ]:
26-36/39
[ RIDADR ]:
UN 2611 6
[ WGK Germany ]:
3
[ RTECS ]:
UA8942000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
[ HS Code ]:
2905590090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2905590090
[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
Natl. Toxicol. Program Tech. Rep. Ser. 477 , 1-264, (1998)
1-Chloro-2-propanol and its positional isomer, 2-chloro-1-propanol, are used as chemical intermediates for the manufacture of propylene oxide, a starting material for production of polyurethane polyol...
Chemical mutagenesis testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program.Environ. Mol. Mutagen. 23(1) , 51-63, (1994)
Fifty chemicals were tested for mutagenic activity in post-meiotic and meiotic germ cells of male Drosophila melanogaster using the sex-linked recessive lethal (SLRL) assay. As in the previous studies...
Haloperoxidases: Enzymatic Synthesis of alpha,beta-Halohydrins from Gaseous Alkenes.Appl. Environ. Microbiol. 45(2) , 366-74, (1983)
The enzymatic synthesis of alpha,beta-halohydrins from gaseous alkenes is described. The enzymatic reaction required an alkene, a halide ion, dilute hydrogen peroxide, and a haloperoxidase enzyme. A w...