2-(Dimethylamino)ethanol

Names

[ CAS No. ]:
108-01-0

[ Name ]:
2-(Dimethylamino)ethanol

[Synonym ]:
2-hydroxy-N,N-dimethyl-benzamide
N,N-dimethyl-salicylamide
2-Dimethylaminoethanol
N,N-Dimethyl-salicylamid
salicylic acid dimethylamide
MFCD00002846
N,N-dimethyl-2-hydroxybenzamide
EINECS 203-542-8
2-(dimethylamino)-1-ethanol
Salicylamide,N,N-dimethyl
Deanol
DMAE
N,N-Dimethylethanolamine
N,N-Dimethyl ethanolamine
2-(Dimethylamino)ethanol
N,N-dimethyl-2-aminoethanol
N,N-dimethylethan-1-ol-2-amine
2-hydroxyethyl-dimethylamine
Salicyldimethylamide
Ethanol, 2-(dimethylamino)-
N,N-dimethyl-2-hydroxyethylamine
Benzamide,2-hydroxy-N,N-dimethyl
2-Hydroxy-N,N-diemethylbenzamide

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
135.0±0.0 °C at 760 mmHg

[ Melting Point ]:
−70 °C(lit.)

[ Molecular Formula ]:
C₄H₁₁NO

[ Molecular Weight ]:
89.136

[ Flash Point ]:
40.6±0.0 °C

[ Exact Mass ]:
89.084061

[ PSA ]:
23.47000

[ LogP ]:
-0.33

[ Vapour Pressure ]:
3.4±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.433

[ Stability ]:
Stable. Flammable. Incompatible with oxidizing agents, copper, copper alloys, zinc, acids, galvanised iron. Hygroscopic.

[ Water Solubility ]:
miscible

[ Freezing Point ]:
-59.0℃

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KK6125000

CHEMICAL NAME :: Ethanol, 2-dimethylamino-

CAS REGISTRY NUMBER :: 108-01-0

BEILSTEIN REFERENCE NO. :: 1209235

LAST UPDATED :: 199806

DATA ITEMS CITED :: 17

MOLECULAR FORMULA :: C4-H11-N-O

MOLECULAR WEIGHT :: 89.16

WISWESSER LINE NOTATION :: Q2N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Open irritation test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 12/15/1971 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZHYGAM Zeitschrift fuer die Gesamte Hygiene und Ihre Grenzgebiete. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1955- Volume(issue)/page/year: 20,393,1974

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1641 ppm/4H

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,512,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1080 mg/kg

TOXIC EFFECTS :: Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - true cholinesterase

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 12,486,1968

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3250 mg/m3

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - convulsions or effect on seizure threshold

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 14(11),52,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 234 mg/kg

TOXIC EFFECTS :: Behavioral - ataxia

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 94,249,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 961 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - coma Lungs, Thorax, or Respiration - other changes

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 225,428,1955

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1370 uL/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU. Volume(issue)/page/year: 4,119,1951

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 85,642,1954 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 670 mg/m3/4H/22W-I

TOXIC EFFECTS :: Endocrine - changes in adrenal weight Blood - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 14(11),52,1970

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 288 ppm/6H/2W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - corneal damage Behavioral - food intake (animal) Related to Chronic Data - death

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,512,1987

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 76 ppm/6H/13W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 9,512,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83678 No. of Facilities: 249 (estimated) No. of Industries: 9 No. of Occupations: 23 No. of Employees: 6372 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83678 No. of Facilities: 1838 (estimated) No. of Industries: 44 No. of Occupations: 36 No. of Employees: 33474 (estimated) No. of Female Employees: 5559 (estimated)

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H302 + H312-H314-H331

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive

[ Risk Phrases ]:
R10;R20/21/22;R34

[ Safety Phrases ]:
S25-S26-S36/37/39-S45

[ RIDADR ]:
UN 2051 8/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
KK6125000

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2922192210

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2922192210

[ Summary ]:
2922192210 2-(diethylamino)ethanol。supervision conditions:3(export license for dual-use item and technologies)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:30.0%

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Related Compounds

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