Cochliodone A

Names

[ Name ]:
Cochliodone A

[Synonym ]:
3H-Cyclotridec[d]oxireno[f]isoindole-7,8,11,12(4H,13H)-tetrone, 9,10,14,14a,15,15a,16a,16b-octahydro-14-(1H-indol-3-ylmethyl)-4,6,15,15a-tetramethyl-, (1Z,4S,5Z,11aR,14S,14aR,15S,15aR,16aS,16bR)-
(1Z,4S,5Z,11aR,14S,14aR,15S,15aR,16aS,16bR)-14-(1H-Indol-3-ylmethyl)-4,6,15,15a-tetramethyl-9,10,14,14a,15,15a,16a,16b-octahydro-3H-cyclotrideca[d]oxireno[f]isoindole-7,8,11,12(4H,13H)-tetrone

Biological Activity

[Description]:

Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 μg/mL (V. vulnificus), 32.7 μg/mL (V. rotiferianus), 15.9 μg/mL (S. aureus ATCC 43300), and 16.3 μg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC50s of 28.1 μM (A549), 20.7 μM (HeLa), and 23.2 μM (Hep G2)[1].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Wang W, et al. Chlorinated Azaphilone Pigments with Antimicrobial and Cytotoxic Activities Isolated from the Deep Sea Derived Fungus Chaetomium sp. NA-S01-R1. Mar Drugs. 2018 Feb 13;16(2):61..

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
774.1±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C₃₄H₃₈O₁₂

[ Molecular Weight ]:
638.66

[ Flash Point ]:
421.9±32.9 °C

[ Exact Mass ]:
528.262451

[ LogP ]:
3.45

[ Vapour Pressure ]:
0.0±2.7 mmHg at 25°C

[ Index of Refraction ]:
1.633

Related Compounds

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