1,1,1,2,2-Pentafluoro-7-phenyl-3-heptanone

Names

[ Name ]:
1,1,1,2,2-Pentafluoro-7-phenyl-3-heptanone

[Synonym ]:
1,1,1,2,2-Pentafluoro-7-phenyl-3-heptanone
3-Heptanone, 1,1,1,2,2-pentafluoro-7-phenyl-
Phospholipase A
FKGK 11

Biological Activity

[Description]:

FKGK11 is a potent and selective inhibitor of GVIA iPLA2 (Group VIA calcium-independent phospholipase A2). FKGK11 can be used for the research of ovarian cancer and neurological disorders such as peripheral nerve injury and multiple sclerosis[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[Target]

PLA2

[In Vitro]

FKGK11 shows 99.4 ± 0.1% inhibition of GVIA iPLA2 and only 28 ± 1% for GV sPLA2 at 0.091 mole fraction[1]. FKGK11 reduces adhesion, migration, and invasion of EOC (epithelial ovarian cancer) cells[2].

[In Vivo]

FKGK11 inhibits tumor development in the xenograft mouse model[2]. FKGK11 shows a significant increase in the number of macrophages and degenerating fibres with disrupted myelin sheaths in cPLA2 GIVA−/− mice and C57BL/6 mice[3].

[References]

[1]. Kokotos G, et al. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10.

[2]. Yan Xu, et al. Abstract 3525: Targeting Group VIA phospholipase A2 using small molecules for ovarian cancer treatment. Cancer Res (2011) 71 (8_Supplement): 3525.

[3]. López-Vales R, et al. Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain. 2008 Oct;131(Pt 10):2620-31.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
288.9±40.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₃H₁₃F₅O

[ Molecular Weight ]:
280.234

[ Flash Point ]:
110.7±21.5 °C

[ Exact Mass ]:
280.088654

[ PSA ]:
17.07000

[ LogP ]:
5.40

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.434

MSDS

Click to get detail MSDS

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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