Hymenidin

Names

[ Name ]:
Hymenidin

[Synonym ]:
hymenidin

Biological Activity

[Description]:

Hymenidin is a natural antagonist of serotonergic receptor and inhibitor of voltage-gated potassium channels. Hymenidin also induces cancer cell apoptosis[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[References]

[1]. Kobayashi J, et al. A novel antagonist of serotonergic receptors, hymenidin, isolated from the Okinawan marine sponge Hymeniacidon sp. Experientia. 1986 Oct 15;42(10):1176-7.

[2]. Zidar N, et al. Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels. Eur J Med Chem. 2017 Oct 20;139:232-241.

[3]. Tihomir Tomašič, et al. Analogues of the marine alkaloids oroidin, clathrodin, and hymenidin induce apoptosis in human HepG2 and THP-1 cancer cells. MedChemComm. 2015, 6(1): 105-110.

Chemical & Physical Properties

[ Density]:
1.69g/cm3

[ Molecular Formula ]:
C₁₁H₁₂BrN₅O

[ Molecular Weight ]:
310.15000

[ Exact Mass ]:
309.02300

[ PSA ]:
99.59000

[ LogP ]:
2.49780

[ Index of Refraction ]:
1.742

Related Compounds

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