Hexamethyldisiloxane
Names
[ CAS No. ]:
107-46-0
[ Name ]:
Hexamethyldisiloxane
[Synonym ]:
HMDSO
EINECS 203-492-7
CH7310
kf96l
HX 18
Hexamethyldisiloxane
Fluka AG
ls-7130
HMDO
H7310
os10
SF 0.65
MFCD00008265
Adefovir Impurity 10
Chemical & Physical Properties
[ Density]:
0.8±0.1 g/cm3
[ Boiling Point ]:
100.9±8.0 °C at 760 mmHg
[ Melting Point ]:
−59 °C(lit.)
[ Molecular Formula ]:
C6H18OSi2
[ Molecular Weight ]:
162.378
[ Flash Point ]:
-1 ºC
[ Exact Mass ]:
162.089615
[ PSA ]:
9.23000
[ LogP ]:
4.20
[ Vapour density ]:
>1 (vs air)
[ Vapour Pressure ]:
41.4±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.393
[ Stability ]:
Stable, but moisture sensitive. Highly flammable. Incompatible with strong acids, strong bases, oxidizing agents.
[ Water Solubility ]:
insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- JM9237000
- CHEMICAL NAME :
- Disiloxane, hexamethyl-
- CAS REGISTRY NUMBER :
- 107-46-0
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C6-H18-O-Si2
- MOLECULAR WEIGHT :
- 162.42
- WISWESSER LINE NOTATION :
- 1-SI-1&1&O-SI-1&1&1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- 85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,1225,1986 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8 mL/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 12,590,1993
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- RCRVAB Russian Chemical Reviws (English Translation). Translation of USKHAB. (Royal Soc. of Chemistry, Distribution Centre, Blackhorse Rd., Letchworth, Herts SG6 1HN, UK) V.29- 1960- Volume(issue)/page/year: 38,975,1969
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 16 mL/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis with appropriate anesthesia Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity)
- REFERENCE :
- ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990- Volume(issue)/page/year: 12,590,1993
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 50 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. Volume(issue)/page/year: 30,332,1948 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5873 No. of Facilities: 1013 (estimated) No. of Industries: 28 No. of Occupations: 23 No. of Employees: 16273 (estimated) No. of Female Employees: 986 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS09
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H410
[ Precautionary Statements ]:
P210-P273-P391-P403 + P235-P501
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Flammable
[ Risk Phrases ]:
R11
[ Safety Phrases ]:
S16
[ RIDADR ]:
UN 1993 3/PG 2
[ WGK Germany ]:
3
[ RTECS ]:
JM9237000
[ Packaging Group ]:
II
[ Hazard Class ]:
3
[ HS Code ]:
29310095
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2934999090
[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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