BIBP3226trifluoroacetate

Names

[ Name ]:
BIBP3226trifluoroacetate

Biological Activity

[Description]:

BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect[1][2].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor

[Target]

rNPY Y1 receptor:1.1 nM (Ki)

hNPFF2:79 nM (Ki)

rNPFF:108 nM (Ki)

[In Vivo]

BIBP3226 (0.5, 5μg; i.c.v.) induces an anxiogenic-like effect at the higher dose[1]. Animal Model: Male Wistar rats 270-350 g[1] Dosage: 0.5, 5μg Administration: I.c.v Result: At the dose of 5μg caused an anxiogenic-like effect while the lower dose was ineffective.

[References]

[1]. Mollereau C, et al. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br J Pharmacol. 2001 May;133(1):1-4.

[2]. Kask A, et al. Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: antagonism with diazepam. Eur J Pharmacol. 1996 Dec 19;317(2-3):R3-4.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₉H₃₂F₃N₅O₅

[ Molecular Weight ]:
587.59

Related Compounds

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