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(R)-(-)-O-Desmethyl Venlafaxine D6

Names

[ CAS No. ]:
1062609-96-4

[ Name ]:
(R)-(-)-O-Desmethyl Venlafaxine D6

[Synonym ]:
4-[(1R)-2-{Bis[(2H3)methyl]amino}-1-(1-hydroxycyclohexyl)ethyl]phenol
Phenol, 4-[(1R)-2-(dimethyl-d3-amino)-1-(1-hydroxycyclohexyl)ethyl]-

Biological Activity

[Description]:

(R)-(-)-O-Desmethyl Venlafaxine D6 is the deuterium labeled (R)-(-)-O-Desmethyl Venlafaxine. O-Desmethyl Venlafaxine is an active metabolite of Venlafaxine[1]. Venlafaxine (HY-B0196) is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class[2].

[Related Catalog]:

Research Areas >> Neurological Disease

[References]

[1]. Yijin Liu, et al. Development of an enantioselective assay for simultaneous separation of venlafaxine and O-desmethylvenlafaxine by micellar electrokinetic chromatography-tandem mass spectrometry: Application to the analysis of drug-drug interaction. J Chromatogr A. 2015 Nov 13;1420:119-28.

[2]. F P Bymaste, et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology. 2001 Dec;25(6):871-80.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
403.8±25.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H19D6NO2

[ Molecular Weight ]:
269.412

[ Flash Point ]:
193.2±21.8 °C

[ Exact Mass ]:
269.226196

[ LogP ]:
2.26

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.573

Related Compounds