Desacetylcephapirin sodium

Desacetylcephapirin sodium (Deacetylcephapirin sodium) is an active metabolite of Cephapirin (HY-A0153A). Desacetylcephapirin sodium has antimicrobial against S. aureus and coagulase-negative staphylococci mastitis pathogen[1][2].

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

antibacterial[2]

Desacetylcephapirin sodium exhibits inhibitory activity on Streptococcus dysgalactiae, with MIC50s both of 0.25 µg/mL for clinical and subclinical bacterial strain[2]. Desacetylcephapirin sodium exhibits inhibitory activity on coagulase-negative staphylococci mastitis pathogen, with MIC50s both of 0.12 µg/mL for clinical and subclinical bacterial strain[2].

[1]. B. E. Cabana, et al. Comparative Pharmacokinetics and Metabolism of Cephapirin in Laboratory Animals and Humans. Antimicrob Agents Chemother. 1976 Aug; 10(2): 307–317.

[2]. Cristina S Cortinhas, et al. Minimum inhibitory concentrations of cephalosporin compounds and their active metabolites for selected mastitis pathogens. Am J Vet Res. 2013 May;74(5):683-90.