Desacetylcephapirin sodium

Names

[ Name ]:
Desacetylcephapirin sodium

[Synonym ]:
sodium,(6R,7R)-3-(hydroxymethyl)-8-oxo-7-[(2-pyridin-4-ylsulfanylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Biological Activity

[Description]:

Desacetylcephapirin sodium (Deacetylcephapirin sodium) is an active metabolite of Cephapirin (HY-A0153A). Desacetylcephapirin sodium has antimicrobial against S. aureus and coagulase-negative staphylococci mastitis pathogen[1][2].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[Target]

antibacterial[2]

[In Vitro]

Desacetylcephapirin sodium exhibits inhibitory activity on Streptococcus dysgalactiae, with MIC50s both of 0.25 µg/mL for clinical and subclinical bacterial strain[2]. Desacetylcephapirin sodium exhibits inhibitory activity on coagulase-negative staphylococci mastitis pathogen, with MIC50s both of 0.12 µg/mL for clinical and subclinical bacterial strain[2].

[References]

[1]. B. E. Cabana, et al. Comparative Pharmacokinetics and Metabolism of Cephapirin in Laboratory Animals and Humans. Antimicrob Agents Chemother. 1976 Aug; 10(2): 307–317.

[2]. Cristina S Cortinhas, et al. Minimum inhibitory concentrations of cephalosporin compounds and their active metabolites for selected mastitis pathogens. Am J Vet Res. 2013 May;74(5):683-90.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₄N₃NaO₅S₂

[ Molecular Weight ]:
403.40900

[ Exact Mass ]:
403.02700

[ PSA ]:
176.75000

[ LogP ]:
0.55530

Related Compounds

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