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QX 572

Names

[ CAS No. ]:
1042-42-8

[ Name ]:
QX 572

[Synonym ]:
carcainium chloride
qx-572

Biological Activity

[Description]:

Carcainium chloride (QX 572) is a quaternary derivative of the local anesthetic Lidocaine. Antitussive effect[1][2].

[Related Catalog]:

Research Areas >> Others
Signaling Pathways >> Others >> Others

[References]

[1]. Lavorini F, et al. Antitussive effect of carcainium chloride in patients with chronic cough and idiopathic interstitial pneumonias: A pilot study. Pulm Pharmacol Ther. 2016 Oct;40:91-4.

[2]. Adcock JJ, et al. RSD931, a novel anti-tussive agent acting on airway sensory nerves. Br J Pharmacol. 2003 Feb;138(3):407-16.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H22ClN3O2

[ Molecular Weight ]:
347.83900

[ Exact Mass ]:
347.14000

[ PSA ]:
58.20000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KH2778000
CHEMICAL NAME :
Ethanaminium, N,N-dimethyl-2-oxo-N-(2-oxo-2-(phenylamino)ethyl)-2-( phenylamino)-, chloride
CAS REGISTRY NUMBER :
1042-42-8
LAST UPDATED :
199204
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C18-H22-N3-O2.Cl
MOLECULAR WEIGHT :
347.88

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 50,212,1987

Related Compounds