Nec-4
Names
[ CAS No. ]:
1041644-43-2
[ Name ]:
Nec-4
Biological Activity
[Description]:
Nec-4, a tricyclic derivative, is a potent receptor interacting protein 1 (RIP1) inhibitor, with an IC50 of 2.6 μM, Ki of 0.46 μM.
[Related Catalog]:
[Target]
IC50: 2.6 μM (RIP1)[1].
[In Vitro]
Nec-4 (compound 9) is a slightly better competitor than 7 with a lower Ki value that is similar to R-3. Nec-4 is again a slightly better competitor than Rac-3 with Ki and IC50 values comparable to 7 (Nec-4: IC50=2.6±0.1 μM, Ki=0.46±0.05 μM; 7: IC50=10.7±1.8 μM, Ki=4.5±0.9 μM). Overall, all three compounds cross-compete with each other but Nec-4 is able to more effectively displace both 20 and 26 in comparison to the parent compounds Rac-3 and 7, respectively. This suggests that Nec-4 binding likely significantly overlaps with both the Nec-1 and the Nec-3 binding sites.
[References]
[Related Small Molecules]
Chemical & Physical Properties
[ Molecular Formula ]:
C15H13ClFN3O
[ Molecular Weight ]:
305.73