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Budesonide impurity C

Names

[ CAS No. ]:
1040085-99-1

[ Name ]:
Budesonide impurity C

[Synonym ]:
(4aR,4bS,5S,6aS,7aR,10aR,11aS,11bS)-5-Hydroxy-7a-(hydroxymethyl)-4a,6a-dimethyl-9-propyl-4b,6,6a,7a,10a,11,11a,11b,12,13-decahydrochryseno[2,3-d][1,3]dioxole-2,7(4aH,5H)-dione
Chryseno[2,3-d][1,3]dioxole-2,7(4aH,5H)-dione, 4b,6,6a,7a,10a,11,11a,11b,12,13-decahydro-5-hydroxy-7a-(hydroxymethyl)-4a,6a-dimethyl-9-propyl-, (4aR,4bS,5S,6aS,7aR,10aR,11aS,11bS)-
Budesonide Impurity 3

Biological Activity

[Description]:

Budesonide impurity C is an impurity of Budesonide. Budesonide, an inhaled glucocortical steroid, is an orally active glucocorticoid receptor agonist[1][2].

[Related Catalog]:

Research Areas >> Cancer
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor

[In Vitro]

Budesonide is selective for human glucocorticoid receptor (hGR; EC50=45.7 pM) over mineralocorticoid receptors (EC50=7,620 pM) in CV-1 cells[1]. Budesonide (30 min prior to LPS) suppresses the activation of the NLRP3 inflammasome by LPS (100 ng/mL) plus ATP (5 mM) in macrophages (RAW 264.7 cells)[2].

[References]

[1]. Patrizia Ferraboschi, et al. Estimation and Characterisation of Budesonide Tablets Impurities. J Pharm Biomed Anal. 2008 Jul 15;47(3):636-40.

[2]. Claudia Grossmann, et al. Transactivation via the Human Glucocorticoid and Mineralocorticoid Receptor by Therapeutically Used Steroids in CV-1 Cells: A Comparison of Their Glucocorticoid and Mineralocorticoid Properties. Eur J Endocrinol. 2004 Sep;151(3):397-406.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
607.0±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C25H34O6

[ Molecular Weight ]:
430.534

[ Flash Point ]:
204.6±25.0 °C

[ Exact Mass ]:
430.235535

[ LogP ]:
2.56

[ Vapour Pressure ]:
0.0±3.9 mmHg at 25°C

[ Index of Refraction ]:
1.592

Related Compounds

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