Ganoderic acid S

Names

[ Name ]:
Ganoderic acid S

Biological Activity

[Description]:

Ganoderic acid S is a positional isomer of ganoderic acids, that can be isolated from the fermented mycelia of Ganoderma lucidum. Ganoderic acid S can induce apoptosis in HeLa cells through the mitochondria pathway[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

[In Vitro]

Ganoderic acid S (0, 39.1, 97.7 μM; 12 h) 在 HeLa 细胞中导致细胞周期停滞在 S 期[1]。 Ganoderic acid S 剂量依赖性地导致线粒体膜电位的崩溃。Ganoderic acid S 诱导细胞色素 c 从线粒体大量释放到 HeLa 细胞的胞质溶胶中[1]。 Cell Cycle Analysis[1] Cell Line: HeLa cells Concentration: 0, 39.1, 97.7 μM Incubation Time: 12 h Result: Caused cell cycle arrest in the S phase.

[References]

[1]. Liu RM, et al. Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. Phytomedicine. 2011 Mar 15;18(5):349-55.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₂H₄₈O₅

[ Molecular Weight ]:
512.72

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.