PF-03654746 Tosylate

Names

[ Name ]:
PF-03654746 Tosylate

[Synonym ]:
unii-v600i6h7t6

Biological Activity

[Description]:

PF-03654746 Tosylate is a potent and selective histamine H3 receptor antagonist with high brain penetration. PF-03654746 Tosylate reduces allergen-induced nasal symptoms[1]. PF-03654746 Tosylate has potential for treatment of human cognitive disorders, improves cognitive efficacy and disease-modifying effects in Alzheimer's disease (AD)[2].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

H3 receptor[1]

[References]

[1]. Stokes JR, et al. The effects of an H3 receptor antagonist (PF-03654746) with fexofenadine on reducing allergic rhinitis symptoms. J Allergy Clin Immunol. 2012 Feb;129(2):409-12, 412.e1-2.

[2]. Brioni JD, et al. Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease. J Pharmacol Exp Ther. 2011 Jan;336(1):38-46.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₃₂F₂N₂O₄S

[ Molecular Weight ]:
494.59400

[ Exact Mass ]:
494.20500

[ PSA ]:
98.58000

[ LogP ]:
6.23310

Related Compounds

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