Purfalcamine

Purfalcamine is a potent, specific inhibitor of Plaasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) with IC50 of 17 nM; inhibits proliferation of P falciparum strains (Dd2, FCB, HB3 and W2) with nanomolar EC50s of (171–259 nM); blocks microneme discharge and erythrocyte invasion by P. falciparum merozoites; an anti-malaria parasite agent.

References 1. Kato N, et al. Nat Chem Biol. 2008 Jun;4(6):347-56. 2. Bansal A, et al. J Biol Chem. 2013 Jan 18;288(3):1590-602. 3. Gaji RY, et al. Antimicrob Agents Chemother. 2014 May;58(5):2598-607. View Related Products by Target Parasite