1038620-68-6
1038620-68-6 structure
- Name: Purfalcamine
- Chemical Name: Purfalcamine
- CAS Number: 1038620-68-6
- Molecular Formula: C29H33FN8O
- Molecular Weight: 528.636
- Catalog: Research Areas Infection
- Create Date: 2020-01-11 21:50:50
- Modify Date: 2024-04-07 16:57:05
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Purfalcamine is a potent, specific inhibitor of Plaasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) with IC50 of 17 nM; inhibits proliferation of P falciparum strains (Dd2, FCB, HB3 and W2) with nanomolar EC50s of (171–259 nM); blocks microneme discharge and erythrocyte invasion by P. falciparum merozoites; an anti-malaria parasite agent.
| Name | Purfalcamine |
|---|
| Description | Purfalcamine is a potent, specific inhibitor of Plaasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1) with IC50 of 17 nM; inhibits proliferation of P falciparum strains (Dd2, FCB, HB3 and W2) with nanomolar EC50s of (171–259 nM); blocks microneme discharge and erythrocyte invasion by P. falciparum merozoites; an anti-malaria parasite agent. |
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| References | References 1. Kato N, et al. Nat Chem Biol. 2008 Jun;4(6):347-56. 2. Bansal A, et al. J Biol Chem. 2013 Jan 18;288(3):1590-602. 3. Gaji RY, et al. Antimicrob Agents Chemother. 2014 May;58(5):2598-607. View Related Products by Target Parasite |
| Molecular Formula | C29H33FN8O |
|---|---|
| Molecular Weight | 528.636 |