Halichondrin B

Names

[ Name ]:
Halichondrin B

[Synonym ]:
halichondrin B

Biological Activity

[Description]:

Halichondrin B is found from the sponge Halichondria okadai. Halichondrin B is a noncompetitive inhibitor of Vinca-alkaloid binding to tubulin (IC50 for tubulin polymerization of 1.2-1.4 μM). Halichondrin B shows anti-tumor activity[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

Halichondrin B (0.1-10 nM, 16 h) treatment inhibits the growth of L1210 cells[1]. Cell Cytotoxicity Assay[1] Cell Line: L1210 cells Concentration: 0.1-10 nM Incubation Time: 16 hours Result: Inhibited L1210 cell with IC50 value of 0.3 nM.

[References]

[1]. Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data. J Biol Chem. 1991 Aug 25;266(24):15882-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₆₀H₈₆O₁₉

[ Molecular Weight ]:
1111.31000

[ Exact Mass ]:
1110.58000

[ PSA ]:
216.21000

[ LogP ]:
4.92540

Related Compounds

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