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PF 6274484

Names

[ CAS No. ]:
1035638-91-5

[ Name ]:
PF 6274484

[Synonym ]:
PF-6274484
MFCD30182370
2-Propenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-
N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-2-propenamide
N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}acrylamide

Biological Activity

[Description]:

PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively).

[In Vitro]

PF-6274484 is an inhibitor of the EGF receptor (EGFR; IC50s = 0.18 and 0.14 nM for wild-type EGFR and inhibitor-resistant EGFRL858R/T790M, respectively).It inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells (IC50s = 5.8 and 6.6 nM, respectively).

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
578.3±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C18H14ClFN4O2

[ Molecular Weight ]:
372.781

[ Flash Point ]:
303.5±30.1 °C

[ Exact Mass ]:
372.078918

[ LogP ]:
3.87

[ Vapour Pressure ]:
0.0±1.6 mmHg at 25°C

[ Index of Refraction ]:
1.691

[ Storage condition ]:
-20°C

Related Compounds

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