CRT5

Names

[ Name ]:
CRT5

[Synonym ]:
Benzamide, 3-[6-amino-5-(6-ethoxy-2-naphthalenyl)-3-pyridinyl]-N-[2-(dimethylamino)ethyl]-
MFCD29081160
3-[6-Amino-5-(6-ethoxy-2-naphthyl)-3-pyridinyl]-N-[2-(dimethylamino)ethyl]benzamide
CRT5

Biological Activity

[Description]:

CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis[1].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> PKD

Research Areas >> Others

[References]

[1]. Evans IM, et al. Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochem J. 2010 Aug 1;429(3):565-72.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
651.2±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₈H₃₀N₄O₂

[ Molecular Weight ]:
454.563

[ Flash Point ]:
347.6±31.5 °C

[ Exact Mass ]:
454.236877

[ LogP ]:
5.22

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.632

Related Compounds

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